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KMID : 0359720240420010048
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Journal of the Korean Neurological Association
2024 Volume.42 No. 1 p.48 ~ p.52
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Coexistence of Anti-Hu and Anti-SOX1 Autoantibodies in Atezolizumab-related Encephalitis
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Eun Mi-Yeun
Hah Hyung-Seok
Hwang Jae-Chun
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Abstract
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Although immune checkpoint inhibitor-related encephalitis has been reported, its underlying mechanism and treatment strategies remain unclear. Here, we present the case of a 60-yearold male patient with small cell lung cancer who developed autoimmune encephalitis during treatment with atezolizumab. Notably, this case involved the concurrent detection of two paraneoplastic autoantibodies (anti-Hu and anti-SOX1). Encephalitis was treated by discontinuing atezolizumab and administering steroids, despite the persistence of the antibodies. This case provides insights into the interaction between immune checkpoint inhibitors and paraneoplastic autoantibodies.
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KEYWORD
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Atezolizumab, Encephalitis, immune checkpoint inhibitors
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